Current Research Projects

We currently have three main research streams in the lab:

Memory Destabilization and Updating

For several years, we have investigated the nature of reactivation-based memory destabilization and updating. Our past work has implicated the cholinergic system in object memory destabilization, and we are currently studying the molecular bases of this role, as well as its generalizabilty to other forms of memory and the effects of ACh on memory storage dynamics. This work is currently funded by NSERC.

GABA and Object Representations

Inhibitory transmission is essential to normal brain function. We are interested in how various GABAergic inhibitory interneuron subtypes regulate encoding and long-term storage of object memory representations.

Early Life Enrichment and Alzheimer’s Disease Model Mice

Alzheimer’s disease (AD) is characterized by distinctive pathological brain changes and cognitive impairment. However, some people can sustain significant levels of AD pathology without displaying cognitive symptoms. Cognitive reserve theory posits that enriched life experiences can help individuals to develop resistance to the effects of AD pathology. In collaboration with Dr. Bruce McNaughton, we are testing this hypothesis in transgenic mouse models of AD provided with varying levels of environmental enrichment. This work is currently funded by CIHR.