(* co-first authors)
For a full list of publications, please visit Google Scholar:
https://scholar.google.ca/citations?user=h4rJikoAAAAJ&hl=en
Huff, E.A., O’Neill, O.S., Messer, W.S., & Winters, B.D. (2024). Muscarinic receptor activation promotes destabilization and updating of object location memories in mice. Behavioural Brain Research, in press.
Abouelnaga, K., Huff, A.E., O’Neill, O.S., Messer, W.S., & Winters, B.D. (2023). Activating M1 muscarinic cholinergic receptors induces destabilization of resistant contextual fear memories in rats. Neurobiology of Learning and Memory, 205, 107821.
Sanchez-Roige, S., Jennings, M.V., Thorpe, H.H.A., Mallari, J.E., van der Werf. L., Bianchi, S.B., Lee, C., Mallard, T.T., Barnes, S.A., Wu, J.Y., Barkley-Levenson, A.M., Boussaty, E.C., Schafer, D., Snethlage, C., Babic, Z., Winters, B.D., Watters, K.E., Biederer, T., 23andMe Research Team, Mackillop, J., Stephens, D.N., Elson, S.L., Fontanillas, P., Khokhar, J.Y., Young, J.W., Palmer, A.A. (2023). CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Translational Psychiatry, 13, 167.
Wideman, C.E., Huff, A.E., Messer, W.S., & Winters, B.D. (2023). Muscarinic receptor activation overrides boundary conditions on memory updating in a calcium/calmodulin-dependent manner. Neuropsychopharmacology, 48, 1358-1366.
Wolter, M., Lapointe, T., Baidoo, N., Mitchnick, K.A., Wideman, C.A., Winters, B.D., & Leri, F. (2023). Double dissociation of perirhinal nicotinic acetylcholine receptors and dopamine D2 receptors in modulation of object memory consolidation by nicotine, cocaine and their conditioned stimuli. European Neuropsychopharmacology, 72, 50-59.
Wideman, C.E., Minard, E.P., Zacharia, J.M., Capistrano, J.D.R., Scott, G.A., & Winters, B.D. (2022). Dissociating the involvement of muscarinic and nicotinic cholinergic receptors in object memory destabilization and reconsolidation. Neurobiology of Learning and Memory, 195, 107686.
Gattas, S., Collett, H. A., Huff, A.E., Creighton, S.D., Weber, S.E., Buckhalter, S., Manning, S.A., Ryait, H.S., McNaughton, B.L., & Winters, B.D. (2022). A rodent obstacle course for controlled environmental enrichment enhances complex cognitive functions. npj Science of Learning, 7, 21. https://doi.org/10.1038/s41539-022-00134-x.
Narkaj, K., Singh, G., Brimble, M.A., Stefanelli, G.,Hall, M., Mitchnick, K.A., Creighton, S.D., Ianov, L., Winters, B.D., Walters, B., Davidoff, A.M., Mitchell, J., Zovkic, I.B. (2022). The histone variant macroH2A1 is a stronger regulator of learning-induced gene expression and memory formation compared to macroH2A2 in mice. Communications Biology, 5, 482. https://doi.org/10.1038/s42003-022-03435-4
Jardine, K.H.*, Huff, A.E.*, Wideman, C.E.*, McGraw, S., & Winters, B.D. (2022). The evidence for and against reactivation-induced memory updating in humans and nonhuman animals. Neuroscience and Biobehavioral Reviews, 136, 104598.
Creighton, S.D., Jardine, K.H., Desimone, A., Zmetana, M., Castellano, S., Milite, C., Sbardella, G.& Winters, B.D. (2022). Age-dependent attenuation of spatial memory deficits by the histone acetyltransferase p300/CBP Associated Factor (PCAF) in 3xTG Alzheimer’s disease mice. Learning & Memory, 29, 71-76.
Huff, A.E., McGraw, S., & Winters, B.D. (2022). Muscarinic (M1) cholinergic receptor activation within the dorsal hippocampus promotes destabilization of strongly encoded object location memories. Hippocampus, 32, 55-66.
Wolter, M., Lapointe, T., Melanson, B., Baidoo, N., Winters, B.D., & Leri, F. (2021). Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists. Psychopharmacology, 238(9), 2617-2628.
Wideman, C.E., Nguyen, J., Jeffries, S., & Winters, B.D. (2021). Fluctuating levels of NMDA receptor subunit proteins in perirhinal cortex relate to their dynamic roles in object memory destabilization and reconsolidation. International Journal of Molecular Sciences, 22, 67.
Hamidullah, S., Lutelmowski, C.D., Creighton, S.D., Luciani, K.R., Frie, J.A., Winters, B.D., & Khokhar, J. (2021). Effects of Vapourized THC and Voluntary Alcohol Drinking During Adolescence on Cognition, Reward, and Anxiety-like Behaviours in Rats. Progress in Neuropsychopharmacology & Biological Psychiatry, 106, 110141. doi: 10.1016/j.pnpbp.2020.110141.
Baidoo, N., Wolter, M., Holohan, M., Winters, B.D., & Leri, F. (2021). The effects of morphine withdrawal and conditioned withdrawal on object memory and c-fos expression in the central nucleus of the amygdala. Addiction Biology, 26(2). 1-11.
Jardine, K.H.*, Wideman, C.E.*, MacGregor, C.C., Sgarbossa, C., Orr, D., Mitchnick, K.A., & Winters. B.D. (2020). Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating. Scientific Reports, 10: 9209; https://doi.org/10.1038/s41598-020-65836-x.
Mendell, A.L., Creighton, S., Wilson, H., Isaacs, L., Jardine, K., Winters, B.D., & MacLusky, N.J. (2020). Inhibition of 5a reductase impairs cognitive performance, alters dendritic morphology and increases tau phosphorylation in the hippocampus of male 3xTg-AD mice. Neuroscience, 429, 185-202.
Wolter, M., Huff, E., Baidoo, N., Jardine, K., Pulles, Z., Winters, B.D., & Leri, F. (2020). Modulation of object memory consolidation by heroin and heroin-conditioned stimuli: role of opioid and noradrenergic systems. European Neuropsychopharmacology, 33, 146-157.
Beraldo, F.H.*, Palmer, D.*, Wasserman, D.I., Lee, W.V., Liang, S., Kouchehbagh, S.M., Creighton, S.C., Kolisnyk, B., Cowan, M.F., Mels, J., Masood, T.S., Fodor,C., Al-Onaizi, M.A., Bartha, R., Gee, T., Saksida, L.M., Bussey, T.J., Strother, S.S., Prado, V. F., Winters, B.D. & Prado, M.A.M. (2019). MouseBytes, an open-access high throughput pipeline and database for rodent touchscreen-based cognitive assessment. eLife; 8: e49630; DOI: https://doi.org/10.7554/eLife.49630.
Creighton, S.D.*, Collett, H.A.*, Zonneveld, P.M., Pandit, R.A., Huff, A.E., Jardine, K.H., McNaughton, B.L., and Winters, B.D. (2019). Development of an “object category recognition task” for mice: involvement of muscarinic acetylcholine receptors. Behavioral Neuroscience, 133, 527-536.
Mitchnick, K.A., Mendell, A.L., Wideman, C.E., Jardine, K.H., Creighton, S.D., Mueller, A., Choleris, E., MacLusky, N.J., & Winters, B.D. (2019). Dissociable involvement of estrogen receptors in perirhinal cortex-mediated object-place memory in male rats. Psychoneuroendocrinology, 107, 98-108.
Duong, A.T.H., Reitz, C.J., Louth, E.L., Creighton, S.D., Rasouli, M., Zwaiman, A., Kroetsch, J.T., Bolz, S., Winters, B.D., Bailey, C.D.C., & Martino, T.A. (2019). The clock mechanism influences neurobiology and adaptations to heart failure in clock∆19/∆19 mice with implications for circadian medicine. Scientific Reports, 9: 4994; DOI:10.1038/s41598-019-41469-7.
Creighton, S.D., Mendell, A.L., Palmer, D., Kalisch, B.E., MacLusky, N.J., Prado, V. F., Prado, M. A. M., & Winters, B.D. (2019). Dissociable cognitive impairments in two strains of transgenic Alzheimer’s disease mice revealed by a battery of object-based tests. Scientific Reports, 9: 57;DOI:10.1038/s41598-018-37312-0.
Wolter, M., Huff, E., Speigel, T., Winters, B.D., & Leri. F. (2019). Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats. Learning & Memory, 26, 46-55.
Wideman, C.E., Jardine, K.H., & Winters, B.D. (2018). Involvement of classical neurotransmitter systems in memory reconsolidation: focus on destabilization. Neurobiology of Learning and Memory, 156, 68-79.
Creighton, S.D., Palmer, D., Mitchnick, K.A., & Winters, B.D. (2018). Exploiting novelty and oddity exploratory preferences in rodents to study multisensory object memory and perception. In A. Ennaceur & M. de Souza Silva (Eds), Handbook of Research on Object Novelty Recognition (pp. 103-123). London: Elsevier.
Mitchnick, K.A., Wideman, C., Huff, A.E., Palmer, D., McNaughton, B., & Winters, B.D. (2018). Development of novel tasks for studying view-invariant object recognition in rodents: sensitivity to scopolamine. Behavioral Brain Research, 344, 48-56.
Stiver, M.L., Cloke, J.M., Nightingale, N., Rizos, J., & Winters, B.D. (2017). Linking muscarinic receptor activation to UPS-mediated object memory destabilization: implications for long-term memory modification and storage. Neurobiology of Learning and Memory, 145, 151-164.
Cloke, J.M., Nguyen, R., Chung, B. Y. T., Wasserman, D.I., De Lisio, S., Kim, J.C., Bailey, C.D.C., & Winters, B.D. (2016). A novel multisensory integration task reveals robust deficits in rodent models of schizophrenia: converging evidence for remediation via nicotinic receptor stimulation of inhibitory transmission in the prefrontal cortex. Journal of Neuroscience, 36, 12570-12585. Featured Article.
Mitchnick, K.A., Creighton, S.D., van Tiggelen, M., Zaika, O., O’Hara, M., Christen, B., Cloke, J.M., Kalisch, B.E., & Winters, B.D. (2016). Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus- and perirhinal cortex-mediated object memory. Genes, Brain, and Behavior, 15, 542-557.
Palmer, D., Creighton, S.D., Prado, V.F., Prado, M.A.M., Choleris, E., & Winters, B.D. (2016). Mice deficient for striatal Vesicular Acetylcholine Transporter (VAChT) display impaired short-term but normal long-term object recognition memory. Behavioural Brain Research, 311, 267-278.
Jacklin, D.L., Cloke, J.M., Potvin, A., Garrett, I., & Winters, B.D. (2016). The dynamic multisensory engram: neural circuitry underlying crossmodal object recognition in rats changes with the nature of object experience. Journal of Neuroscience, 36, 1273-1289.
Mitchnick, K.A., Creighton, S.D., O’Hara, M., Kalisch, B.E., & Winters, B.D. (2015). Dissociable contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex. European Journal of Neuroscience, 41, 773-786.
Stiver, M.L., Jacklin, D.L., Mitchnick, K.A, Vicic, N., Carlin, J., O’Hara, M., & Winters, B.D. (2015). Cholinergic manipulations bidirectionally regulate object memory destabilization. Learning & Memory, 22, 203-214.
Sticht, M.A., Jacklin, D.L., Parker, L.A., & Winters, B.D. (2015). Intra-perirhinal cortex administration of the synthetic cannabinoid, HU210, disrupts object recognition memory in rats. NeuroReport, 26, 258-262.
Cloke, J.M., Jacklin, D.L., & Winters, B.D. (2014). The neural bases of crossmodal object recognition in non-human primates and rodents: a review. Behavioural Brain Research, 285, 118-130.
Reid, J.M., Jacklin, D.L., & Winters, B.D. (2014). Delineating prefrontal cortex region contributions to crossmodal object recognition in rats. Cerebral Cortex, 24, 2108-2119.
Rkieh, N., Cloke, J.M., Gallagher, N., Winters, B.D., & Leri, F. (2014). Drugs of abuse as memory modulators: a study of cocaine in rats. Psychopharmacology, 231, 2339-2348.
Flavell, C.R., Lambert, E., Winters, B.D., & Bredy, T.W. (2013). Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. Frontiers in Behavioral Neuroscience, 7:214. doi: 10.3389/fnbeh.2013.00214
Jacklin, D.L., Goel, A., Clementino, K., Hall, A., Talpos, J.C., & Winters, B.D. (2012). Severe crossmodal object recognition deficits in rats treated sub-chronically with NMDA receptor antagonists are reversed by systemic nicotine: implications for abnormal multisensory integration in schizophrenia. Neuropsychopharmacology, 37, 2322-2331.
Winters, B.D., Tucci, M.C., Jacklin, D.L., Reid, J.M., & Newsome, J. (2011). On the dynamic nature of the engram: evidence for circuit-level reorganization of object memory traces following reactivation. Journal of Neuroscience, 31, 17719-17728.
McTighe S.M., Cowell, R.A., Winters, B.D., Bussey, T.J., & Saksida, L.M. (2010). Paradoxical false memory for objects after brain damage. Science, 330, 1408-1410.
Winters, B.D., Bussey, T.J., & Saksida, L.M. (2010). Implications of animal object memory research for human amnesia. Neuropsychologia, 48, 2251-2261.
Winters, B.D. & Reid, J.M. (2010). A distributed cortical representation underlies crossmodal object recognition in rats. Journal of Neuroscience, 30, 6253-6261.
Winters, B.D., Tucci, M.C, & DaCosta-Furtado, M. (2009). Older and stronger object memories are selectively destabilized by reactivation in the presence of new information. Learning and Memory, 16, 545-553.